phone-number
vets

Go to site For Pet Owners

Insulin control

Insulin resistance

Stress, infections, and obesity

Stress or infections (urinary tract infections, pyoderma) can lead to a decline in the sensitivity of target tissues to insulin. Obese animals have reduced insulin sensitivity.

Other hormones

Endogenous or exogenous hormones may reduce the effects of insulin. When treating an animal for diabetes mellitus, medication with progestogens should be discontinued immediately. Intact queens should be spayed.

If animals are being treated with corticosteroids, alternatives to this treatment should be sought. If this is not feasible, efforts should be made to minimize the corticosteroid dose.

See the following graph for an example of a blood glucose curve in a case of insulin resistance. Insulin was injected at time=0 hours.

Blood glucose curve

Blood glucose measured in mg/dL
Click on thumbnail for full image:

Solution

  • Investigate cause, eg, Cushing’s disease, hyperprogesteronism, owner issues, injection issues, or use of the wrong type of syringe
  • Consider Somogyi overswing, which can present as persistent hyperglycemia for a few days following the hypoglycemic event

Rapid metabolism of insulin

Problem—the duration of action of insulin is less than desired (10–12 hours for twice-daily administration). See the following graph for an example of a blood glucose curve in a case of rapid metabolism of insulin. Insulin was injected at time=0 hours.

Blood glucose curve

Blood glucose measured in mg/dL
Click on thumbnail for full image:

Solution

  • Change to a longer-acting preparation

See About glucose curves for details on making a glucose curve.

top