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Potential diabetes

Potential diabetes mellitus, defined as impaired insulin synthesis and/or decreased sensitivity of tissue receptors to the effects of insulin, results in an increased blood glucose concentration that does not exceed the renal threshold.

Intact females may exhibit potential diabetes mellitus during diestrus. The elevated progesterone level is antagonistic to the action of insulin. At this stage, the problem may still be reversible by ovariohysterectomy, thus eliminating the progesterone source.