Go to site For Pet Owners

Vetsulin efficacy and safety

Canine efficacy and safety study results

Proven efficacy and safety in dogs

Vetsulin® (porcine insulin zinc suspension) achieved glycemic control and reduced clinical signs in diabetic dogs in FDA-licensing study:2

  • Treated dogs demonstrated significantly lower blood glucose levels following treatment with Vetsulin. Investigators reported adequate glycemic control an average of 81% of time during the study period.
  • Treated dogs demonstrated reduced hyperglycemic clinical signs following treatment with Vetsulin.
  • 94%, 96%, and 83% of test dogs experienced a reduction in polyuria, polydipsia, and ketonuria, respectively.

Proven safety in use over a prolonged period of time

  • Vetsulin has a proven track record of safety and effectiveness in the US and international markets.
  • Vetsulin gives practitioners the additional confidence of more than 20 years of successful worldwide use under the brand names of Vetsulin and Caninsulin®.

Feline efficacy and safety study results

Proven efficacy in cats

Vetsulin reduced all major diabetes indicators, including hyperglycemic signs, to within normal range and was well tolerated in a US pivotal study of 78 cats.2,3

The study results showed:

  • 75% of cats had a mean blood glucose level <300 mg/dL by Day 60 following Vetsulin treatment.
  • 72% of cats had a mean glucose nadir <200 mg/dL by Day 60 after Vetsulin treatment.
  • The mean blood glucose nadir was 145.7 mg/dL by Day 60.
  • Fructosamine was significantly reduced on Days 30, 60, and 180 compared to Day 0.

Click on icon for full image:

Chart showing mean blood glucose nadir cats

Average blood glucose nadir on Days 7, 14, 30, 60, and 180 was reduced
compared to Day 0 (pretreatment initiation).

Cat dosing information

In this study, cats were initially started on 1 to 2 IU of Vetsulin per injection twice daily. Glycemic control was evaluated based on blood glucose curves and clinical signs. Adjustment of the Vetsulin dose was made according to average blood glucose curve levels, blood glucose curve nadirs, and clinical improvement. At the end of the study, the mean Vetsulin dose was 3.3 IU per injection BID with a maximum dose of 8 IU per injection twice daily. Five percent of the cats in the study went into diabetic remission.

Feline safety study results

FDA-licensing study demonstrated that Vetsulin was well tolerated.2,3

  • Clinical signs of hypoglycemia, which were generally mild, occurred in only 16.7% of test cats.
  • All cases resolved with symptomatic treatment or dose adjustment.