About Vetsulin

Vetsulin efficacy and safety

Canine efficacy and safety study results

Proven efficacy and safety in dogs
Vetsulin achieved glycemic control and reduced clinical signs in diabetic dogs in FDA-licensing study1:

  • Test dogs demonstrated significantly lower blood glucose levels following treatment with Vetsulin® (porcine insulin zinc suspension). Investigators reported adequate glycemic control an average of 81% of time during the study period.
  • Test dogs demonstrated reduced hyperglycemic clinical signs following treatment with Vetsulin.
  • 94%, 96%, and 83% of test dogs experienced a reduction in polyuria, polydipsia, and ketonuria, respectively.

Proven safety in use over a prolonged period of time

  • Vetsulin has a proven track record of safety and effectiveness in use in both US and international veterinary practices.
  • Vetsulin gives practitioners the additional confidence of over 15 years of successful international use under the brand name Caninsulin®.

Feline efficacy and safety study results

Proven efficacy in cats
Vetsulin reduced all major diabetes indicators, including hyperglycemic signs, to within normal range and was well tolerated in US pivotal study of 78 cats.1,2

The study results showed:

  • 75% of cats had a mean blood glucose level of <300 mg/dL by Day 60 following Vetsulin treatment.
  • 72% of cats had a mean glucose nadir of <200 mg/dL by Day 60 after Vetsulin treatment.
  • The mean blood glucose nadir was 145.7 by Day 60.
  • Fructosamine was significantly reduced on Days 30, 60, and 180 compared to Day 0.

Click on icon for full image:

Average blood glucose nadir on Days 7, 14, 30, 60, and 180 was reduced compared to Day 0 (pretreatment initiation).

Cat dosing information
In this study, cats were initially started on 1 to 2 IU of Vetsulin per injection twice daily. Glycemic control was evaluated based on blood glucose curves and clinical signs. Adjustment of the Vetsulin dose was made according to average blood glucose curve levels, blood glucose curve nadirs, and clinical improvement. At the end of the study, the Vetsulin dose ranged from 0 to 8 IU per injection BID.

Feline safety study results
FDA-licensing study demonstrated that Vetsulin was well tolerated1, 2

  • Clinical signs of hypoglycemia occurred in only 16.7% of test cats.
  • Clinical signs were generally mild.
  • All cases resolved with symptomatic treatment or dose adjustment.

1. Freedom of Information Summary. NADA 141-236, Approved by FDA. April 1, 2004 and March 24, 2008.
2. Data on file, Intervet/Schering-Plough Animal Health.