Potential diabetes mellitus, defined as impaired insulin synthesis and/or decreased sensitivity of tissue receptors to the effects of insulin, results in an increased blood glucose concentration that does not yet exceed the renal threshold.
Potential diabetes mellitus is seen in intact bitches during diestrus. At this stage, the problem may still be reversible by ovariohysterectomy, thus eliminating the progesterone source. Mild hyperglycemia may also be encountered in canine Cushing’s syndrome. Here, too, reversal of the cortisol excess may prevent the development of diabetes mellitus.